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灌注系統(tǒng)概述

HSE—HA生理學(xué)系統(tǒng)是一系列應(yīng)用廣泛的完備產(chǎn)品，可用于整體動(dòng)物生理學(xué)、立體或在體器官和組織灌注及組織浴槽研究。這些系統(tǒng)具有廣泛的應(yīng)用，包括傳統(tǒng)的安全藥理學(xué)、DMPK、毒理學(xué)、呼吸系統(tǒng)、心臟病學(xué)、分子生物學(xué)和生理學(xué)。每個(gè)系統(tǒng)都設(shè)計(jì)了標(biāo)準(zhǔn)的組件，再加一些其他配置以適合特殊研究的需要。。標(biāo)注組件也意味著如果你是需要將現(xiàn)有設(shè)備配齊，或者進(jìn)行系統(tǒng)升級(jí)，或者是完整的配套產(chǎn)品，你都只需要購(gòu)買需要的構(gòu)件。HSE-HA生理學(xué)系統(tǒng)為你提供各種工具，使你的研究走向多產(chǎn)和成功。

我們提供大多數(shù)生理學(xué)檢測(cè)設(shè)備，包括放大器、電極、傳感器和電化學(xué)檢測(cè)器。參數(shù)包括力、位移、壓力、液體和氣體流、心電圖（單導(dǎo)聯(lián)—12導(dǎo)統(tǒng)）、MAP（單個(gè)或多個(gè)部位）、腦電圖、*、連續(xù)支流灌注傳統(tǒng)的血?dú)鈪?shù)和電解質(zhì)的分析，可以選擇程序化軟件和傳統(tǒng)的刺激器作為放大器、電極和傳感器等產(chǎn)品的補(bǔ)充。

HSE-DAQ系統(tǒng)產(chǎn)品家族（BDAS、ACAD、HAEMODYN、ISOHEART、PULMODYN、PENNOCK）可以記錄你的初始信號(hào)，計(jì)算到處的參數(shù)，注釋數(shù)據(jù)，快速簡(jiǎn)易的輸入確定的數(shù)據(jù)用于分析。同時(shí)還可以選擇用于進(jìn)一步分析的軟件模塊，帶狀記錄紙打印，自動(dòng)和控制模塊等。產(chǎn)品經(jīng)過預(yù)先設(shè)置，打開包裝即可使用，并專門設(shè)計(jì)符合你的系統(tǒng)配置和數(shù)據(jù)分析要求。

The Isolated Heart Size 9 has been developed to perform experiments with hearts from small pigs with a body weight up to about 10 kg (heart weight 40 g). The system can be operated in any one of the three methods (Constant Pressure CP, Constant Flow CF, Working Heart WH). The perfusion flow is limited to 500 ml/min for retrograde perfusion and the aortic flow to 1.5 l/min for a working heart system. The system allows standard haemodynamic as well as ischemia-reperfusion studies using saline or erythrocytes containing perfusion solutions. The complete apparatus is mounted on a trolley. It consists of the jacketed heart chamber, its cover with the connections to the heart, pumps, thermostatic circulator and measuring system.

Special Version:

For heart transplantation and cardioplegia studies, the apparatus is equipped with a special option. With this option the heart can be perfused from a second perfusion circuit in retrograde mode using a different perfusion solution (e.g., perfluorocarbon emulsion). Cardioplegia solutions can be injected or infused through a dedicated port.

• Isolated perfused small pig heart (heart weight up to 40 g) in retrograde perfusion

• Working heart mode, the special flow resistance and compliance chamber mimics closely the in-vivo afterload

• Compact, easy to use

• Special version for cardioplegia studies in heart transplant studies

• Applications: - Studies of recovery in heart transplantation

- Studies of cardioplegia techniques and solutions

- Evaluation of pacemaker

The main part of the apparatus is the cover of the heart chamber. The aortic block is mounted on this cover. In the working heart version the preload reservoir is mounted on the cover and consequently located into the heart chamber. The large heart chamber serves as perfusate reservoir. The chamber can be moved down during the preparation with a lift-system. The way of functioning is identical to the isolated heart system size 5, see page K4.

Saline perfusion solutions are oxygenated by bubbling in the chamber using a frit. If erythrocytes-containing perfusates are used, a membrane oxygenator as used in the heart-lung machine is necessary.

The measured signals as well as the computed parameters in the different modes are the same for the Isolated Heart Setup Size 9 as for the setup IH-SR 5. The size of the flowprobes must be adapted to the corresponding diameters.