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IL-2離體肺灌注系統(tǒng)的概述
hse—ha生理學系統(tǒng)是一系列應用廣泛的完備產(chǎn)品，可用于整體動物生理學、立體或在體器官和組織灌注及組織浴槽研究。這些系統(tǒng)具有廣泛的應用，包括傳統(tǒng)的安全藥理學、dmpk、毒理學、呼吸系統(tǒng)、心臟病學、分子生物學和生理學。每個系統(tǒng)都設計了標準的組件，再加一些其他配置以適合特殊研究的需要。。標注組件也意味著如果你是需要將現(xiàn)有設備配齊，或者進行系統(tǒng)升級，或者是完整的配套產(chǎn)品，你都只需要購買需要的構件。hse-ha生理學系統(tǒng)為你提供各種工具，使你的研究走向多產(chǎn)和成功。
我們提供大多數(shù)生理學檢測設備，包括放大器、電極、傳感器和電化學檢測器。參數(shù)包括力、位移、壓力、液體和氣體流、心電圖（單導聯(lián)—12導統(tǒng)）、map（單個或多個部位）、腦電圖、*、連續(xù)支流灌注傳統(tǒng)的血氣參數(shù)和電解質的分析，可以選擇程序化軟件和傳統(tǒng)的刺激器作為放大器、電極和傳感器等產(chǎn)品的補充。
hse-daq系統(tǒng)產(chǎn)品家族（bdas、acad、haemodyn、isoheart、pulmodyn、pennock）可以記錄你的初始信號，計算到處的參數(shù)，注釋數(shù)據(jù)，快速簡易的輸入確定的數(shù)據(jù)用于分析。同時還可以選擇用于進一步分析的軟件模塊，帶狀記錄紙打印，自動和控制模塊等。產(chǎn)品經(jīng)過預先設置，打開包裝即可使用，并專門設計符合你的系統(tǒng)配置和數(shù)據(jù)分析要求。
• optimized in-situ preparation
• negative-pressure ventilation to mimic more closely the invivo situation
• regular induction of hyperinflation of the lung （sigh, augmented breath）
• several perfusion modes using buffer solution or blood are available:
– constant flow perfusion
– constant pressure perfusion
– dual perfusion system（constant flow or constant pressure can be se-lected）
• continuous measurement of lung mechanics （tidal volume, resistance, compliance）, and perfusate characteristics （pressure, flow, po2, pco2, ph）
• continuous measurement of lung weight （edema）
ventilation
the lung is placed in the artificial thoracic chamber and ventilated at negative pressure, it is connected via the tracheal cannula to the pneumotachometer for measurement of respiratory flow. the humidified ventilation medium （air or gas mixture） is constantly flowing past the distal end of the pneumotachometer.
perfusion
lungs can be perfused by either constant flow or constant pressure. although constant flow perfusion may mimic the in vivo situation more closely, it has the disadvantage that hydrostatic edema becomes inevitable during vasoconstriction. constant pressure perfusion permits higher perfusate flow rates since vasoconstriction decreases perfusate flow and hydrostatic edema is less likely to occur.
can be configured in one of three different perfusion modes:
1. constant flow perfusion
2. constant pressure perfusion
3. dual system to switch from constant flow to constant pressure and vice versa
lung weight changes
continuous measurement of weight changes of the lung is required for monitoring edema formation. this is possible during negative pressure ventilation inside the thoracic chamber by using the hse-edema balance ls 30 （weight transducer） （bs4 73-0593）, range ±30 g, displacement 2 µm/gram. weight changes induced by raising or lowering the perfusion pressure can be used to assess vascular permeability by determining the filtration coefficient.
• optimized in-situ preparation
• negative-pressure ventilation to mimic more closely the invivo situation
• regular induction of hyperinflation of the lung （sigh, augmented breath）
• several perfusion modes using buffer solution or blood are available:
– constant flow perfusion
– constant pressure perfusion
– dual perfusion system（constant flow or constant pressure can be se-lected）
• continuous measurement of lung mechanics （tidal volume, resistance, compliance）, and perfusate characteristics （pressure, flow, po2, pco2, ph）
• continuous measurement of lung weight （edema）
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